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HomeImpact of COVID-19Impact of
COVID-19Uncovering the Burden of DiseaseCOVID-19 & Flu ImpactSelect UMCs & Risk FactorsAbout COMIRNATYAbout COMIRNATYIntroductionmRNA TechnologyCOMIRNATY Clinical Trial OverviewCOMIRNATY Pivotal TrialSelect Safety DataRWEReal-World EvidenceRCTs and RWE AnalysesRWE Study Design: 2023-2024 Formula of COMIRNATY in Individuals 18 Years and Older2023-2024 Formula of COMIRNATY RWEAdditional RWE InformationDosing & AdministrationResourcesResourcesLinks & SupportCOMIRNATY Health Plan CoverageMaterialsHypothetical Patient ProfilesSusan is 68 years oldMike has asthmaMaria has coronary artery diseaseTom has type 2 diabetes
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Links & SupportFind helpful links for ordering, customer service, and resources right here.cart icon Ordering available through Pfizer Prime*

Orders for 2025-2026 formula COVID-19 vaccines by BioNTech and Pfizer can be placed by eligible healthcare professionals directly with Pfizer through Pfizer Prime online or by calling 1‑800‑533‑4535.

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*Eligible healthcare providers can order COVID-19 vaccines directly from Pfizer. If preferred, orders may be placed with your facility’s wholesaler.

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To help support conversations with your patients about what vaccines they may need:

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COMIRNATY Health Plan Coverage
COMIRNATY Health Plan Coverage
Susan is 68 years old.Susan enjoys this chapter of her life.
She's focused on spending time visiting her grandchildren, and she understands it is important to get a COVID-19 vaccination. Your recommendation matters.1
Susan enjoys this chapter of her life.

She's focused on spending time visiting her grandchildren, and she understands it is important to receive COVID-19 vaccinations. Your recommendation matters.1

According to the CDC, Susan’s age puts her at higher risk for severe outcomes from COVID-192*

Age remains the strongest risk factor for severe outcomes from COVID-19, with increased risk for individuals who are 65 years of age and older.2

The United States Centers for Disease Control and Prevention (CDC) defines severe outcomes of COVID-19 as hospitalization, admission to the intensive care unit (ICU), intubation or mechanical ventilation, or death.2

Help protect eligible individuals against COVID-19 with COMIRNATY3,4

Risk of experiencing severe outcomes from COVID-19
Please refer to https://www.cdc.gov/covid/php/covid-net/index.html for the most current information related to COVID-NET data collection. 

To learn more about certain underlying medical conditions that increase the risk for experiencing severe outcomes from COVID-19, visit cdc.gov
These websites are neither owned nor controlled by Pfizer. Pfizer is not responsible for the content or services of these sites.Hospitalization rates were calculated as the number of residents in a surveillance area hospitalized with laboratory-confirmed SARS-CoV-2, divided by the total population estimate for that area. Rates presented are COVID-19–associated hospitalizations per 100,000 population.5COVID-19–associated hospitalizations defined as laboratory-confirmed SARS-CoV-2 in a person who lives in a defined COVID-NET surveillance area and tests positive for SARS-CoV-2 within 14 days before or during hospitalization.5Among individuals 18-29 years of age, COVID-19–associated hospitalization rates ranged from 1.1 to 2.5 per 100,000 from October 2024 to March 2025.5COVID-NET=Coronavirus Disease 2019 (COVID-19) Hospitalization Surveillance Network; SARS-CoV-2=severe acute respiratory syndrome coronavirus 2.Why your recommendation matters to patients like Susan

According to the CDC:

Many adults are not aware of which vaccines they are recommended to receive, including a COVID-19 vaccine1

A healthcare professional’s recommendation can be a strong predictor of whether a patient gets vaccinated1

Research suggests that when patients are given a vaccine recommendation and are offered a vaccine at the same time, they are more likely to get vaccinated1

The CDC has published additional considerations related to COVID-19 vaccination for individuals who are 65 years of age and older or who are moderately or severely immunocompromised6

According to the CDC, coadministration of age-appropriate vaccines is recommended if there are no contraindications at time of healthcare visit. Review every patient’s immunization history at every healthcare visit to assess for needed vaccines.6,7||

Reviewing vaccination history can help determine whether Susan is eligible for coadministration of a COVID-19 vaccine and other vaccines if she is due at the same visit and no contraindications exist.6,7
There are additional considerations for simultaneous administration of an orthopoxvirus vaccine and COVID-19 vaccine. For best practices for administering multiple injections, see ACIP General Best Practice Guidelines for Immunization.6ACIP=Advisory Committee on Immunization Practices. < Back All Patient Profiles Loading
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Mike has asthma LoadingReferences:Adult immunization standards. Centers for Disease Control and Prevention. Updated August 9, 2024. Accessed June 10, 2025. https://www.cdc.gov/vaccines-adults/hcp/imz-standards/index.htmlUnderlying conditions and the higher risk for severe COVID-19. Centers for Disease Control and Prevention. Updated February 6, 2025. Accessed June 10, 2025. https://www.cdc.gov/covid/hcp/clinical-care/underlying-conditions.htmlStaying up to date with COVID-19 vaccines. Centers for Disease Control and Prevention. Updated June 6, 2025. Accessed June 10, 2025. https://www.cdc.gov/covid/vaccines/stay-up-to-date.htmlCOMIRNATY® (COVID-19 Vaccine, mRNA). Prescribing Information. BioNTech Manufacturing GmbH and Pfizer Inc.; August 27, 2025.COVID-NET interactive dashboard. Centers for Disease Control and Prevention. Accessed June 10, 2025. https://www.cdc.gov/covid/php/covid-net/index.htmlInterim clinical considerations for use of COVID-19 vaccines in the United States. Centers for Disease Control and Prevention. Updated May 1, 2025. Accessed June 10, 2025. https://www.cdc.gov/covid/hcp/vaccine-considerations/index.htmlVaccine administration: before giving vaccine. Centers for Disease Control and Prevention. Updated July 10, 2025. Accessed August 7, 2025. https://www.cdc.gov/vaccines/hcp/administration/before.htmlPanagiotakopoulos L, Moulia DL, Godfrey M, et al. Use of COVID-19 vaccines for persons aged ≥6 months: recommendations of the Advisory Committee on Immunization Practices—United States, 2024-2025. MMWR Morb Mortal Wkly Rep. 2024;73(37):819-824. doi:10.15585/mmwr.mm7337e2
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INDICATION
COMIRNATY® (COVID-19 Vaccine, mRNA) is a vaccine indicated for active immunization to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

COMIRNATY is approved for use in individuals who are:
• 65 years of age and older, or
• 5 years through 64 years of age with at least one underlying condition that puts them at high risk for severe outcomes from COVID-19.
Important Safety InformationDo not administer COMIRNATY® (COVID-19 Vaccine, mRNA) to individuals with known history of a severe allergic reaction (e.g., anaphylaxis) to any component of COMIRNATY or to individuals who had a severe allergic reaction (e.g., anaphylaxis) following a previous dose of a Pfizer-BioNTech COVID-19 vaccine.Management of Acute Allergic ReactionsAppropriate medical treatment must be immediately available to manage potential anaphylactic reactions following administration of COMIRNATY.

Myocarditis and Pericarditis

Postmarketing data from use of authorized or approved mRNA COVID-19 vaccines, including COMIRNATY, have demonstrated increased risks of myocarditis and pericarditis, with onset of symptoms typically in the first week following vaccination. The observed risk has been highest in males 12 years through 24 years of age.

SyncopeSyncope (fainting) may occur in association with administration of injectable vaccines, including COMIRNATY. Procedures should be in place to avoid injury from fainting.Altered ImmunocompetenceImmunocompromised persons, including individuals receiving immunosuppressant therapy, may have a diminished immune response to COMIRNATY.Limitation of Vaccine EffectivenessCOMIRNATY may not protect all vaccine recipients.Adverse ReactionsMost commonly reported adverse reactions after a dose:
  • 12 years of age and older (≥10%) were pain at the injection site (up to 90.5%), fatigue (up to 77.5%), headache (up to 75.5%), chills (up to 49.2%), muscle pain (up to 45.5%), joint pain (up to 27.5%), fever (up to 24.3%), injection site swelling (up to 11.8%), and injection site redness (up to 10.4%).
  • 5 years through 11 years of age (≥5%) were pain at the injection site (up to 83.8%), fatigue (up to 51.9%), headache (up to 38.4%), injection site redness (up to 25.9%), injection site swelling (up to 20%), muscle pain (up to 18.1%), chills (up to 13.3%), fever (up to 7.8%), and joint pain (up to 7.6%).
To report SUSPECTED ADVERSE REACTIONS, contact Pfizer Inc. at 1-800-438-1985
or https:/www.pfizersafetyreporting.com or VAERS at 1-800-822-7967 or https://vaers.hhs.govPlease click for COMIRNATY Full Prescribing Information and Patient Information. Indication
COMIRNATY is a vaccine indicated for active immunization to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

COMIRNATY is approved for use in individuals who are:
• 65 years of age and older, or
• 5 years through 64 years of age with at least one underlying condition that puts them at high risk for severe outcomes from COVID-19.