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HomeImpact of COVID-19Impact of
COVID-19Uncovering the Burden of DiseaseCOVID-19 & Flu ImpactSelect UMCs & Risk FactorsAbout COMIRNATYAbout COMIRNATYIntroductionmRNA TechnologyCOMIRNATY Clinical Trial OverviewCOMIRNATY Pivotal TrialSelect Safety DataRWEReal-World EvidenceRCTs and RWE AnalysesRWE Study Design: 2023-2024 Formula of COMIRNATY in Individuals 18 Years and Older2023-2024 Formula of COMIRNATY RWEAdditional RWE InformationDosing & AdministrationResourcesResourcesLinks & SupportCOMIRNATY Health Plan CoverageMaterialsHypothetical Patient ProfilesSusan is 68 years oldMike has asthmaMaria has coronary artery diseaseTom has type 2 diabetes
IndicationPrescribing InformationPatient InformationPatient SiteOrder on Pfizer PrimePediatric Information (5 years & older)
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COMIRNATY Coverage

Patient Profiles

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Links & SupportFind helpful links for ordering, customer service, and resources right here.cart icon Ordering available through Pfizer Prime*

Orders for 2025-2026 formula COVID-19 vaccines by BioNTech and Pfizer can be placed by eligible healthcare professionals directly with Pfizer through Pfizer Prime online or by calling 1‑800‑533‑4535.

CDC Adult Immunization Schedule

CDC Adult Immunization Schedule

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Visit Pfizer Prime

*Eligible healthcare providers can order COVID-19 vaccines directly from Pfizer. If preferred, orders may be placed with your facility’s wholesaler.

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Live representatives are available to help answer COMIRNATY health plan coverage questions.
Hours M-F, 8 AM to 8 PM ET

Call 1-866-744-3198image CDC Resource

To help support conversations with your patients about what vaccines they may need:

CDC Adult Immunization Schedule

By clicking the above link, you will be redirected to a website that is neither owned nor controlled by Pfizer. Pfizer is not responsible for the content or services of this site.

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For questions or issues related to shipping and handling of COVID-19 vaccines from Pfizer and BioNTech.

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COMIRNATY Health Plan Coverage
COMIRNATY Health Plan Coverage
Mike is 35 years old and has asthma.Mike has big plans for his future. 

He is juggling two jobs as a receptionist and a server to support himself, his family, and his future aspirations. He understands it is
important to get a COVID-19 vaccination. Your recommendation matters.1

Mike has big plans for his future. 

He is juggling two jobs as a receptionist and a server to support himself, his family, and his future aspirations. He understands it is
important to receive COVID-19 vaccinations. Your recommendation matters.1

According to the CDC, Mike’s asthma puts him at higher risk for severe outcomes from COVID-192*

The United States Centers for Disease Control and Prevention (CDC) defines severe outcomes of COVID-19 as hospitalization, admission to the intensive care unit (ICU), intubation or mechanical ventilation, or death.2

Help protect eligible individuals against COVID-19 with COMIRNATY3,4

Risk of experiencing severe outcomes from COVID-19

Individuals with certain underlying medical conditions, including asthma, are at a higher risk of experiencing severe outcomes from COVID-19.2

The CDC recognizes asthma and certain chronic lung diseases as underlying medical conditions associated with higher risk of experiencing severe outcomes from COVID-19.2

Chronic lung diseases with higher risk are limited to2:

  • Bronchiectasis
  • Chronic obstructive pulmonary disease (COPD)
  • Interstitial lung disease
  • Pulmonary embolism
  • Pulmonary hypertension

To learn more about certain underlying medical conditions that increase the risk for experiencing severe outcomes from COVID-19, visit cdc.gov

This website is neither owned nor controlled by Pfizer. Pfizer is not responsible for the content or services of this site.

CDC recommendation

The CDC considers asthma an underlying medical condition that increases a patient’s risk of severe outcomes2

The CDC recommends eligible individuals stay up to date with COVID-19 vaccination(s)6,8

To learn more about certain underlying medical conditions that increase the risk for experiencing severe outcomes from COVID-19, visit cdc.gov

This website is neither owned nor controlled by Pfizer. Pfizer is not responsible for the content or services of this site.Why your recommendation matters to patients like Mike

According to the CDC: 

Many adults are not aware of which vaccines they are recommended to receive, including a COVID-19 vaccine1

A healthcare professional’s recommendation can be a strong predictor of whether a patient gets vaccinated1

Research suggests that when patients are given a vaccine recommendation and are offered a vaccine at the same time, they are more likely to get vaccinated1

According to the CDC, coadministration of age-appropriate vaccines is recommended if there are no contraindications at time of healthcare visit. Review every patient’s immunization history at every healthcare visit to assess for needed vaccines.6,7† Reviewing vaccination history can help determine whether Mike is eligible for coadministration of a COVID-19 vaccine and other vaccines if he is due at the same visit and no contraindications exist.6,7 There are additional considerations for simultaneous administration of an orthopoxvirus vaccine and COVID-19
 vaccine. For best practices for administering multiple injections, see ACIP General Best Practice Guidelines for
Immunization.6ACIP=Advisory Committee on Immunization Practices.Risk of experiencing severe outcomes from COVID-19

Individuals with certain underlying medical conditions, including asthma, are at a higher risk of experiencing severe outcomes from COVID-19.2

The CDC recognizes asthma and certain chronic lung diseases as underlying medical conditions associated with higher risk of experiencing severe outcomes from COVID-19.2

Chronic lung diseases with higher risk are limited to2:

  • Bronchiectasis
  • Chronic obstructive pulmonary disease (COPD)
  • Interstitial lung disease
  • Pulmonary embolism
  • Pulmonary hypertension

To learn more about certain underlying medical conditions that increase the risk for experiencing severe outcomes from COVID-19, visit cdc.gov

CDC recommendation The CDC considers asthma an underlying medical condition that increases a patient’s risk of severe outcomes2 The CDC recommends eligible individuals stay up to date with COVID-19 vaccination(s)6,8

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According to the CDC: 

Why your recommendation matters to patients like Mike Many adults are not aware of which vaccines they are recommended to receive, including a COVID-19 vaccine1 A healthcare professional’s recommendation can be a strong predictor of whether a patient gets vaccinated1 Research suggests that when patients are given a vaccine recommendation and are offered a vaccine at the same time, they are more likely to get vaccinated1

According to the CDC, coadministration of age-appropriate vaccines is recommended if there are no contraindications at time of healthcare visit. Review every patient’s immunization history at every healthcare visit to assess for needed vaccines.6,7†

Reviewing vaccination history can help determine whether Mike is eligible for coadministration of a COVID-19 vaccine and other vaccines if he is due at the same visit and no contraindications exist.6,7

There are additional considerations for simultaneous administration of an orthopoxvirus vaccine and COVID-19
 vaccine. For best practices for administering multiple injections, see ACIP General Best Practice Guidelines for
Immunization.6

ACIP General Best Practice Guidelines for Immunization.6

 < Back Susan is 68 years old Loading
Up next >
Maria has CAD LoadingReferences:Adult immunization standards. Centers for Disease Control and Prevention. Updated August 9, 2024. Accessed June 10, 2025. https://www.cdc.gov/vaccines-adults/hcp/imz-standards/index.htmlUnderlying conditions and the higher risk for severe COVID-19. Centers for Disease Control and Prevention. Updated February 6, 2025. Accessed June 10, 2025. https://www.cdc.gov/covid/hcp/clinical-care/underlying-conditions.htmlStaying up to date with COVID-19 vaccines. Centers for Disease Control and Prevention. Updated June 6, 2025. Accessed June 10, 2025. https://www.cdc.gov/covid/vaccines/stay-up-to-date.htmlCOMIRNATY® (COVID-19 Vaccine, mRNA). Prescribing Information. BioNTech Manufacturing GmbH and Pfizer Inc.; August 27, 2025.COVID-NET interactive dashboard. Centers for Disease Control and Prevention. Accessed June 10, 2025. https://www.cdc.gov/covid/php/covid-net/index.htmlInterim clinical considerations for use of COVID-19 vaccines in the United States. Centers for Disease Control and Prevention. Updated May 1, 2025. Accessed June 10, 2025. https://www.cdc.gov/covid/hcp/vaccine-considerations/index.htmlVaccine administration: before giving vaccine. Centers for Disease Control and Prevention. Updated July 10, 2025. Accessed August 7, 2025. https://www.cdc.gov/vaccines/hcp/administration/before.htmlPanagiotakopoulos L, Moulia DL, Godfrey M, et al. Use of COVID-19 vaccines for persons aged ≥6 months: recommendations of the Advisory Committee on Immunization Practices—United States, 2024-2025. MMWR Morb Mortal Wkly Rep. 2024;73(37):819-824. doi:10.15585/mmwr.mm7337e2
Downloadable MaterialsLoading

Downloadable Materials

To learn more about certain underlying medical conditions that increase the risk for experiencing severe outcomes from COVID-19, visit cdc.gov

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INDICATION
COMIRNATY® (COVID-19 Vaccine, mRNA) is a vaccine indicated for active immunization to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

COMIRNATY is approved for use in individuals who are:
• 65 years of age and older, or
• 5 years through 64 years of age with at least one underlying condition that puts them at high risk for severe outcomes from COVID-19.
Important Safety InformationDo not administer COMIRNATY® (COVID-19 Vaccine, mRNA) to individuals with known history of a severe allergic reaction (e.g., anaphylaxis) to any component of COMIRNATY or to individuals who had a severe allergic reaction (e.g., anaphylaxis) following a previous dose of a Pfizer-BioNTech COVID-19 vaccine.Management of Acute Allergic ReactionsAppropriate medical treatment must be immediately available to manage potential anaphylactic reactions following administration of COMIRNATY.

Myocarditis and Pericarditis

Postmarketing data from use of authorized or approved mRNA COVID-19 vaccines, including COMIRNATY, have demonstrated increased risks of myocarditis and pericarditis, with onset of symptoms typically in the first week following vaccination. The observed risk has been highest in males 12 years through 24 years of age.

SyncopeSyncope (fainting) may occur in association with administration of injectable vaccines, including COMIRNATY. Procedures should be in place to avoid injury from fainting.Altered ImmunocompetenceImmunocompromised persons, including individuals receiving immunosuppressant therapy, may have a diminished immune response to COMIRNATY.Limitation of Vaccine EffectivenessCOMIRNATY may not protect all vaccine recipients.Adverse ReactionsMost commonly reported adverse reactions after a dose:
  • 12 years of age and older (≥10%) were pain at the injection site (up to 90.5%), fatigue (up to 77.5%), headache (up to 75.5%), chills (up to 49.2%), muscle pain (up to 45.5%), joint pain (up to 27.5%), fever (up to 24.3%), injection site swelling (up to 11.8%), and injection site redness (up to 10.4%).
  • 5 years through 11 years of age (≥5%) were pain at the injection site (up to 83.8%), fatigue (up to 51.9%), headache (up to 38.4%), injection site redness (up to 25.9%), injection site swelling (up to 20%), muscle pain (up to 18.1%), chills (up to 13.3%), fever (up to 7.8%), and joint pain (up to 7.6%).
To report SUSPECTED ADVERSE REACTIONS, contact Pfizer Inc. at 1-800-438-1985
or https:/www.pfizersafetyreporting.com or VAERS at 1-800-822-7967 or https://vaers.hhs.govPlease click for COMIRNATY Full Prescribing Information and Patient Information. Indication
COMIRNATY is a vaccine indicated for active immunization to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

COMIRNATY is approved for use in individuals who are:
• 65 years of age and older, or
• 5 years through 64 years of age with at least one underlying condition that puts them at high risk for severe outcomes from COVID-19.