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HomeImpact of COVID-19Impact of
COVID-19Uncovering the Burden of DiseaseCOVID-19 & Flu ImpactSelect UMCs & Risk FactorsAbout COMIRNATYAbout COMIRNATYIntroductionmRNA TechnologyCOMIRNATY Clinical Trial OverviewCOMIRNATY Pivotal TrialSelect Safety DataRWEReal-World EvidenceRCTs and RWE AnalysesRWE Study Design: 2023-2024 Formula of COMIRNATY in Individuals 18 Years and Older2023-2024 Formula of COMIRNATY RWEAdditional RWE InformationDosing & AdministrationResourcesResourcesLinks & SupportCOMIRNATY Health Plan CoverageMaterialsHypothetical Patient ProfilesSusan is 68 years oldMike has asthmaMaria has coronary artery diseaseTom has type 2 diabetes
IndicationPrescribing InformationPatient InformationPatient SiteOrder on Pfizer PrimePediatric Information (5 years & older)
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Links & SupportFind helpful links for ordering, customer service, and resources right here.image Ordering available through Pfizer Prime*
Orders for 2025-2026 formula COVID-19 vaccines by BioNTech and Pfizer can be placed by eligible healthcare professionals directly with Pfizer through Pfizer Prime online or by calling
1-800-533-4535.

Visit Pfizer Prime
Orders for 2025-2026 formula COVID-19 vaccines by BioNTech and Pfizer can be placed by eligible healthcare professionals directly with Pfizer through Pfizer Prime online or by calling 1-800-533-4535.

Visit Pfizer Prime

ReferencesEligible healthcare providers can order COVID-19 vaccines directly from Pfizer. if preferred, orders may be placed with your facility's wholesaler.Image Reimbursement Hub 

Live representatives are available to help answer COMIRNATY health plan coverage questions.
Hours M-F, 8 AM to 8 PM ET

Call 1-866-744-3198 image CDC Resource

To help support conversations with your patients about what vaccines they may need:

CDC Adult Immunization Schedule

By clicking the above link, you will be redirected to a website that is neither owned nor controlled by Pfizer. Pfizer is not responsible for the content or services of this site.
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Including general product questions.
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For questions or issues related to shipping and handling of COVID-19 vaccines from Pfizer and BioNTech.

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COMIRNATY Health Plan Coverage COMIRNATY Health Plan Coverage
Hypothetical Patient ProfilesHypothetical Patient ProfilesExplore examples of hypothetical patients with certain underlying medical conditions or risk factors for COVID-19, and learn how to protect them against COVID-19 and potential severe outcomes. Susan is 68 years old Loading Mike has asthma Loading
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Ordering available through Pfizer Prime*Orders for 2025-2026 formula COVID-19 vaccines by BioNTech and Pfizer can be placed by eligible healthcare professionals directly with Pfizer through Pfizer Prime online or by calling 1-800-533-4535.Visit Pfizer PrimeLoading

Eligible healthcare providers can order COVID-19 vaccines directly from Pfizer. If preferred, orders may be placed with your facility’s wholesaler.

References:Adult immunization standards. Centers for Disease Control and Prevention. Updated August 9, 2024. Accessed June 10, 2025. https://www.cdc.gov/vaccines-adults/hcp/imz-standards/index.htmlUnderlying conditions and the higher risk for severe COVID-19. Centers for Disease Control and Prevention. Updated February 6, 2025. Accessed June 10, 2025. https://www.cdc.gov/covid/hcp/clinical-care/underlying-conditions.htmlStaying up to date with COVID-19 vaccines. Centers for Disease Control and Prevention. Updated June 6, 2025. Accessed June 10, 2025. https://www.cdc.gov/covid/vaccines/stay-up-to-date.htmlCOMIRNATY® (COVID-19 Vaccine, mRNA). Prescribing Information. BioNTech Manufacturing GmbH and Pfizer Inc.; August 27, 2025.COVID-NET interactive dashboard. Centers for Disease Control and Prevention. Accessed June 10, 2025. https://www.cdc.gov/covid/php/covid-net/index.htmlInterim clinical considerations for use of COVID-19 vaccines in the United States. Centers for Disease Control and Prevention. Updated May 1, 2025. Accessed June 10, 2025. https://www.cdc.gov/covid/hcp/vaccine-considerations/index.htmlVaccine administration: before giving vaccine. Centers for Disease Control and Prevention. Updated July 10, 2025. Accessed August 7, 2025. https://www.cdc.gov/vaccines/hcp/administration/before.htmlPanagiotakopoulos L, Moulia DL, Godfrey M, et al. Use of COVID-19 vaccines for persons aged ≥6 months: recommendations of the Advisory Committee on Immunization Practices—United States, 2024-2025. MMWR Morb Mortal Wkly Rep. 2024;73(37):819-824. doi:10.15585/mmwr.mm7337e2
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INDICATION
COMIRNATY® (COVID-19 Vaccine, mRNA) is a vaccine indicated for active immunization to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

COMIRNATY is approved for use in individuals who are:
• 65 years of age and older, or
• 5 years through 64 years of age with at least one underlying condition that puts them at high risk for severe outcomes from COVID-19.
Important Safety InformationDo not administer COMIRNATY® (COVID-19 Vaccine, mRNA) to individuals with known history of a severe allergic reaction (e.g., anaphylaxis) to any component of COMIRNATY or to individuals who had a severe allergic reaction (e.g., anaphylaxis) following a previous dose of a Pfizer-BioNTech COVID-19 vaccine.Management of Acute Allergic ReactionsAppropriate medical treatment must be immediately available to manage potential anaphylactic reactions following administration of COMIRNATY.

Myocarditis and Pericarditis

Postmarketing data from use of authorized or approved mRNA COVID-19 vaccines, including COMIRNATY, have demonstrated increased risks of myocarditis and pericarditis, with onset of symptoms typically in the first week following vaccination. The observed risk has been highest in males 12 years through 24 years of age.

SyncopeSyncope (fainting) may occur in association with administration of injectable vaccines, including COMIRNATY. Procedures should be in place to avoid injury from fainting.Altered ImmunocompetenceImmunocompromised persons, including individuals receiving immunosuppressant therapy, may have a diminished immune response to COMIRNATY.Limitation of Vaccine EffectivenessCOMIRNATY may not protect all vaccine recipients.Adverse ReactionsMost commonly reported adverse reactions after a dose:
  • 12 years of age and older (≥10%) were pain at the injection site (up to 90.5%), fatigue (up to 77.5%), headache (up to 75.5%), chills (up to 49.2%), muscle pain (up to 45.5%), joint pain (up to 27.5%), fever (up to 24.3%), injection site swelling (up to 11.8%), and injection site redness (up to 10.4%).
  • 5 years through 11 years of age (≥5%) were pain at the injection site (up to 83.8%), fatigue (up to 51.9%), headache (up to 38.4%), injection site redness (up to 25.9%), injection site swelling (up to 20%), muscle pain (up to 18.1%), chills (up to 13.3%), fever (up to 7.8%), and joint pain (up to 7.6%).
To report SUSPECTED ADVERSE REACTIONS, contact Pfizer Inc. at 1-800-438-1985
or https:/www.pfizersafetyreporting.com or VAERS at 1-800-822-7967 or https://vaers.hhs.govPlease click for COMIRNATY Full Prescribing Information and Patient Information. Indication
COMIRNATY is a vaccine indicated for active immunization to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

COMIRNATY is approved for use in individuals who are:
• 65 years of age and older, or
• 5 years through 64 years of age with at least one underlying condition that puts them at high risk for severe outcomes from COVID-19.