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HomeCOVID-19 ImpactImpact of
COVID-19Uncovering the Burden of DiseaseCOVID-19 & Flu ImpactSelect UMCs & Risk FactorsAbout COMIRNATYAbout COMIRNATYIntroductionmRNA TechnologyCOMIRNATY Clinical Trial OverviewCOMIRNATY Pivotal TrialSelect Safety DataRWEReal-World EvidenceRCTs and RWE Considerations24-25 Appaneal Study Design24-25 Appaneal VE AnalysisDosingPatient ProfilesPatient
ProfilesHypothetical Patient ProfilesSusan is 68 years oldClaire has chronic kidney diseaseMike has asthmaHypothetical Patient ProfilesSusan is 68 years oldClaire has chronic kidney diseaseMike has asthmaMaria has coronary artery diseaseTom has type 2 diabetesMaria has coronary artery diseaseTom has type 2 diabetesHypothetical Patient ProfilesSusan is 68 years oldMike has asthmaMaria has coronary artery diseaseTom has type 2 diabetesResourcesResourcesLinks & SupportCOMIRNATY Health Plan CoverageMaterialsHypothetical Patient ProfilesSusan is 68 years oldMike has asthmaMaria has coronary artery diseaseTom has type 2 diabetes
IndicationPrescribing InformationPatient InformationPatient SiteOrder on Pfizer PrimePediatric Information (5 years & older)
Hypothetical Patient ProfilesSusan is 68 years old.Susan enjoys this chapter of
her life.

She's focused on spending time visiting her grandchildren, and she understands it is important to get a COVID-19 vaccination. Your recommendation matters.1

According to the CDC, Susan’s age puts her at higher risk for severe outcomes from COVID-19.2*Age remains the strongest risk factor for severe outcomes from COVID-19, with increased risk for individuals who are 65 years of age and older.2 
The United States Centers for Disease Control and Prevention (CDC) defines severe outcomes of COVID-19 as hospitalization, admission to the intensive care unit (ICU), intubation or mechanical ventilation, or death.2
Risk of experiencing severe outcomes from COVID-19

Please refer to https://www.cdc.gov/covid/php/covid-net/index.html for the most current information related to COVID-NET data collection. 

To learn more about certain underlying medical conditions that increase the risk for experiencing severe outcomes from COVID-19, visit cdc.gov

The above websites are neither owned nor controlled by Pfizer. Pfizer is not responsible for the content or services of these sites.Hospitalization rates were calculated as the number of residents in a surveillance area hospitalized with laboratory-confirmed SARS-CoV-2, divided by the total population estimate for that area. Rates presented are COVID-19–associated hospitalizations per 100,000 population.3COVID-19–associated hospitalizations defined as laboratory-confirmed SARS-CoV-2 in a person who lives in a defined COVID-NET surveillance area and tests positive for SARS-CoV-2 within 14 days before or during hospitalization.3Among individuals 18-49 years of age, the COVID-19–associated hospitalization rate was 5.3 per 100,000.3COVID-NET=Coronavirus Disease 2019 (COVID-19) Hospitalization Surveillance Network; SARS-CoV-2=severe acute respiratory syndrome coronavirus 2. Why your recommendation matters to patients like SusanAccording to the CDC:

Many eligible adults may not be aware of which vaccines they are eligible for4

A healthcare professional’s recommendation can be a strong predictor of whether a patient gets vaccinated4

Research suggests that when patients are given a vaccine recommendation and are offered a vaccine at the same time, they are more likely to get vaccinated4

The CDC has published additional considerations related to COVID-19 vaccination for individuals who are 65 years of age and older or who are moderately or severely immunocompromised5

According to the CDC, healthcare providers should review every patient’s immunization history at each appointment to assess for needed vaccines. Providers may coadminister a COVID-19 vaccine and other vaccines for eligible individuals like Susan, if no contraindications exist.5,6||

There are additional considerations for simultaneous administration of an orthopoxvirus vaccine and COVID-19 vaccine. For best practices for administering multiple injections, see CDC Interim Clinical Considerations.5Help protect eligible individuals against severe outcomes from COVID-19 with COMIRNATY7,8 < Back All Patient ProfilesLoading
Up next >
 Claire, 52 years old, CKDLoadingReferences:For health care providers. US Department of Health and Human Services. Updated February 20, 2025. Accessed February 10, 2026. https://www.hhs.gov/risk-less-do-more/for-health-care-providers/index.html Underlying conditions and the higher risk for severe COVID-19. Centers for Disease Control and Prevention. Updated February 6, 2025. Accessed February 10, 2026. https://www.cdc.gov/covid/hcp/clinical-care/underlying-conditions.html COVID-NET interactive dashboard. Centers for Disease Control and Prevention. Accessed January 27, 2026.
https://www.cdc.gov/covid/php/covid-net/index.html  Adult immunization standards. Centers for Disease Control and Prevention. Updated August 9, 2024. Accessed February 10, 2026. https://www.cdc.gov/vaccines-adults/hcp/imz-standards/index.htmlInterim clinical considerations for use of COVID-19 vaccines in the United States. Centers for Disease Control and Prevention. Updated November 4, 2025. Accessed February 10, 2026. https://www.cdc.gov/covid/hcp/vaccine-considerations/index.html Vaccine administration: before giving vaccine. Centers for Disease Control and Prevention. Updated July 10, 2025. Accessed February 10, 2026. https://www.cdc.gov/vaccines/hcp/administration/before.html Staying up to date with COVID-19 vaccines. Centers for Disease Control and Prevention. Updated November 19, 2025. Accessed February 10, 2026. https://www.cdc.gov/covid/vaccines/stay-up-to-date.html COMIRNATY® (COVID-19 Vaccine, mRNA). Prescribing Information. BioNTech Manufacturing GmbH and Pfizer Inc.; August 27, 2025.Recommended adult immunization schedule for ages 19 years or older. Centers for Disease Control and Prevention. Updated October 7, 2025. Accessed February 10, 2025. https://www.cdc.gov/vaccines/hcp/imz-schedules/downloads/adult/adult-combined-schedule.pdf Patient Profiles Downloadable Materials Loading

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The formulation of COMIRNATY, which is based on BioNTech proprietary mRNA technology, was developed by BioNTech and Pfizer.  

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INDICATION
COMIRNATY® (COVID-19 Vaccine, mRNA) is a vaccine indicated for active immunization to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

COMIRNATY is approved for use in individuals who are:
• 65 years of age and older, or
• 5 years through 64 years of age with at least one underlying condition that puts them at high risk for severe outcomes from COVID-19.
Important Safety InformationDo not administer COMIRNATY® (COVID-19 Vaccine, mRNA) to individuals with known history of a severe allergic reaction (e.g., anaphylaxis) to any component of COMIRNATY or to individuals who had a severe allergic reaction (e.g., anaphylaxis) following a previous dose of a Pfizer-BioNTech COVID-19 vaccine.Management of Acute Allergic ReactionsAppropriate medical treatment must be immediately available to manage potential anaphylactic reactions following administration of COMIRNATY.

Myocarditis and Pericarditis

Postmarketing data from use of authorized or approved mRNA COVID-19 vaccines, including COMIRNATY, have demonstrated increased risks of myocarditis and pericarditis, with onset of symptoms typically in the first week following vaccination. The observed risk has been highest in males 12 years through 24 years of age.

SyncopeSyncope (fainting) may occur in association with administration of injectable vaccines, including COMIRNATY. Procedures should be in place to avoid injury from fainting.Altered ImmunocompetenceImmunocompromised persons, including individuals receiving immunosuppressant therapy, may have a diminished immune response to COMIRNATY.Limitation of Vaccine EffectivenessCOMIRNATY may not protect all vaccine recipients.Adverse ReactionsMost commonly reported adverse reactions after a dose:
  • 12 years of age and older (≥10%) were pain at the injection site (up to 90.5%), fatigue (up to 77.5%), headache (up to 75.5%), chills (up to 49.2%), muscle pain (up to 45.5%), joint pain (up to 27.5%), fever (up to 24.3%), injection site swelling (up to 11.8%), and injection site redness (up to 10.4%).
  • 5 years through 11 years of age (≥5%) were pain at the injection site (up to 83.8%), fatigue (up to 51.9%), headache (up to 38.4%), injection site redness (up to 25.9%), injection site swelling (up to 20%), muscle pain (up to 18.1%), chills (up to 13.3%), fever (up to 7.8%), and joint pain (up to 7.6%).
To report SUSPECTED ADVERSE REACTIONS, contact Pfizer Inc. at 1-800-438-1985
or https:/www.pfizersafetyreporting.com or VAERS at 1-800-822-7967 or https://vaers.hhs.govPlease click for COMIRNATY Full Prescribing Information and Patient Information. Indication
COMIRNATY is a vaccine indicated for active immunization to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

COMIRNATY is approved for use in individuals who are:
• 65 years of age and older, or
• 5 years through 64 years of age with at least one underlying condition that puts them at high risk for severe outcomes from COVID-19.