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HomeCOVID-19 ImpactImpact of
COVID-19Uncovering the Burden of DiseaseCOVID-19 & Flu ImpactSelect UMCs & Risk FactorsAbout COMIRNATYAbout COMIRNATYIntroductionmRNA TechnologyCOMIRNATY Clinical Trial OverviewCOMIRNATY Pivotal TrialSelect Safety DataRWEReal-World EvidenceRCTs and RWE Considerations24-25 Appaneal Study Design24-25 Appaneal VE AnalysisDosingPatient ProfilesPatient
ProfilesHypothetical Patient ProfilesSusan is 68 years oldClaire has chronic kidney diseaseMike has asthmaHypothetical Patient ProfilesSusan is 68 years oldClaire has chronic kidney diseaseMike has asthmaMaria has coronary artery diseaseTom has type 2 diabetesMaria has coronary artery diseaseTom has type 2 diabetesHypothetical Patient ProfilesSusan is 68 years oldMike has asthmaMaria has coronary artery diseaseTom has type 2 diabetesResourcesResourcesLinks & SupportCOMIRNATY Health Plan CoverageMaterialsHypothetical Patient ProfilesSusan is 68 years oldMike has asthmaMaria has coronary artery diseaseTom has type 2 diabetes
IndicationPrescribing InformationPatient InformationPatient SiteOrder on Pfizer PrimePediatric Information (5 years & older)
Hypothetical Patient ProfilesView profiles that are illustrative of candidates eligible for vaccination against COVID-19 with the 2025-2026 Formula of COMIRNATY. Susan, 68 years old Loading Claire, 52 years old, CKD Loading Mike, 35 years old, asthma Loading Maria, 47 years old, CAD Loading Tom, 61 years old, T2DM LoadingCAD=coronary artery disease; CKD=chronic kidney disease; T2DM=type 2 diabetes mellitus. < Back Dosing Loading
Up next >
 Susan, 68 years old LoadingHeaderOrdering available through Pfizer Prime*

Orders for COMIRNATY 2025-2026 Formula can be placed by eligible healthcare professionals directly with Pfizer through Pfizer Prime online or by calling
1-800-533-4535.

Visit Pfizer Prime

*If preferred, orders may be placed with your facility’s wholesaler.

References:For health care providers. US Department of Health and Human Services. Updated February 20, 2025. Accessed February 10, 2026. https://www.hhs.gov/risk-less-do-more/for-health-care-providers/index.htmlUnderlying conditions and the higher risk for severe COVID-19. Centers for Disease Control and Prevention. Updated February 6, 2025. Accessed February 10, 2026. https://www.cdc.gov/covid/hcp/clinical-care/underlying-conditions.htmlCOVID-NET interactive dashboard. Centers for Disease Control and Prevention. Accessed January 27, 2026. https://www.cdc.gov/covid/php/covid-net/index.html  Adult immunization standards. Centers for Disease Control and Prevention. Updated August 9, 2024. Accessed February 10, 2026. https://www.cdc.gov/vaccines-adults/hcp/imz-standards/index.html  Interim clinical considerations for use of COVID-19 vaccines in the United States. Centers for Disease Control and Prevention. Updated November 4, 2025. Accessed February 10, 2026. https://www.cdc.gov/covid/hcp/vaccine-considerations/index.htmlVaccine administration: before giving vaccine. Centers for Disease Control and Prevention. Updated July 10, 2025. Accessed February 10, 2026. https://www.cdc.gov/vaccines/hcp/administration/before.html Staying up to date with COVID-19 vaccines. Centers for Disease Control and Prevention. Updated November 19, 2025. Accessed February 10, 2026. https://www.cdc.gov/covid/vaccines/stay-up-to-date.htmlCOMIRNATY® (COVID-19 Vaccine, mRNA). Prescribing Information. BioNTech Manufacturing GmbH and Pfizer Inc.; August 27, 2025.Recommended adult immunization schedule for ages 19 years or older. Centers for Disease Control and Prevention. Updated October 7, 2025. Accessed February 10, 2025. https://www.cdc.gov/vaccines/hcp/imz-schedules/downloads/adult/adult-combined-schedule.pdfPatient Profiles Downloadable MaterialsLoading

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Manufactured by
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The formulation of COMIRNATY, which is based on BioNTech proprietary mRNA technology, was developed by BioNTech and Pfizer.  

To report an adverse event, please call 1-800-438-1985

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INDICATION
COMIRNATY® (COVID-19 Vaccine, mRNA) is a vaccine indicated for active immunization to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

COMIRNATY is approved for use in individuals who are:
• 65 years of age and older, or
• 5 years through 64 years of age with at least one underlying condition that puts them at high risk for severe outcomes from COVID-19.
Important Safety InformationDo not administer COMIRNATY® (COVID-19 Vaccine, mRNA) to individuals with known history of a severe allergic reaction (e.g., anaphylaxis) to any component of COMIRNATY or to individuals who had a severe allergic reaction (e.g., anaphylaxis) following a previous dose of a Pfizer-BioNTech COVID-19 vaccine.Management of Acute Allergic ReactionsAppropriate medical treatment must be immediately available to manage potential anaphylactic reactions following administration of COMIRNATY.

Myocarditis and Pericarditis

Postmarketing data from use of authorized or approved mRNA COVID-19 vaccines, including COMIRNATY, have demonstrated increased risks of myocarditis and pericarditis, with onset of symptoms typically in the first week following vaccination. The observed risk has been highest in males 12 years through 24 years of age.

SyncopeSyncope (fainting) may occur in association with administration of injectable vaccines, including COMIRNATY. Procedures should be in place to avoid injury from fainting.Altered ImmunocompetenceImmunocompromised persons, including individuals receiving immunosuppressant therapy, may have a diminished immune response to COMIRNATY.Limitation of Vaccine EffectivenessCOMIRNATY may not protect all vaccine recipients.Adverse ReactionsMost commonly reported adverse reactions after a dose:
  • 12 years of age and older (≥10%) were pain at the injection site (up to 90.5%), fatigue (up to 77.5%), headache (up to 75.5%), chills (up to 49.2%), muscle pain (up to 45.5%), joint pain (up to 27.5%), fever (up to 24.3%), injection site swelling (up to 11.8%), and injection site redness (up to 10.4%).
  • 5 years through 11 years of age (≥5%) were pain at the injection site (up to 83.8%), fatigue (up to 51.9%), headache (up to 38.4%), injection site redness (up to 25.9%), injection site swelling (up to 20%), muscle pain (up to 18.1%), chills (up to 13.3%), fever (up to 7.8%), and joint pain (up to 7.6%).
To report SUSPECTED ADVERSE REACTIONS, contact Pfizer Inc. at 1-800-438-1985
or https:/www.pfizersafetyreporting.com or VAERS at 1-800-822-7967 or https://vaers.hhs.govPlease click for COMIRNATY Full Prescribing Information and Patient Information. Indication
COMIRNATY is a vaccine indicated for active immunization to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

COMIRNATY is approved for use in individuals who are:
• 65 years of age and older, or
• 5 years through 64 years of age with at least one underlying condition that puts them at high risk for severe outcomes from COVID-19.