Dosing and Preparation

Something went wrong

We encountered an unexpected error, we encourage you to try again later.

We're here to help

Should you have additional questions please contact PfizerPro customer service.

Representatives are available:
Monday-Friday 8:00am to 9:00pm Eastern time

Call 1 (800) 505-4426

PP-UNP-USA-5796

Order samples

All samples available online to you are included below. Availability is updated periodically.

PP-UNP-USA-5796

Important Notice

Savings cards will be shipped with Product Samples, if applicable.

Signature

Use your mouse, finger, or stylus to sign below.

Legal Notice

I certify that I am a licensed prescriber, eligible to request and receive the drug samples listed in the quantities indicated. I am also confirming that these samples will be used exclusively for the medical treatment of my patients in conformity with all relevant state and/or local prescribing and dispensing requirements. My signature will also serve as confirmation of my receipt of these medications, if delivered by a company representative, or my intention to acknowledge them upon delivery to my medical office if shipped via common carrier. I understand that these samples cannot be sold, traded, bartered returned for credit or utilized to seek or obtain reimbursement.

Your order has been placed

We have received your order and are getting it ready

More to explore

Patient assistance

Download available co-pay cards and patient savings offers across select Pfizer products.

Explore patient assistance

Vaccines

Find out more about the diseases, treatments and prevention methods that are impacted by our Pfizer Vaccine portfolio.

Explore Vaccines

PP-UNP-USA-5796

Leave ordering?

Changes you have made will not be saved.

This site is intended for U.S. healthcare professionals.

Visit Pfizer Medical

Log Out

Therapy Areas

Products

Order Vaccines

Order Samples

Order

Materials

Request Samples

Hospital Products

Vaccines

Patient Assistance

Pfizer Oncology Together

Pfizer RxPathways

Pfizer Dermatology Patient Access

Explore Content

Contact

Home

Impact of COVID-19

Impact of
COVID-19

Uncovering the Burden of Disease

COVID-19 & Flu Impact

Select UMCs & Risk Factors

About COMIRNATY

Introduction

mRNA Technology

COMIRNATY Clinical Trial Overview

COMIRNATY Pivotal Trial

Select Safety Data

RWE

Real-World Evidence

RCTs and RWE Analyses

Study Design: 2023-2024 Formula RWE

Effectiveness Data: 2023-2024 Formula RWE

Additional RWE Information

Dosing & Preparation

Resources

Links & Support

COMIRNATY Health Plan Coverage

Materials

Hypothetical Patient Profiles

Susan is 68 years old

Mike has asthma

Maria has coronary artery disease

Tom has type 2 diabetes

Indication

Prescribing Information

Patient Information

Patient Site

Order on Pfizer Prime

EUA Vaccine Option for 6 Mo to 11 Years of Age

Dosing and preparation

The first and only mRNA COVID-19 vaccine available from the manufacturer at REFRIGERATED TEMPERATURE (2°C to 8°C [35°F to 46°F]) supplied in a single dose glass prefilled syringe^1-3

Vaccine presentation for eligible individuals 12 years of age and older¹

To prevent vaccine administration errors, prior to preparation and administration: 

Please verify that the single dose glass prefilled syringe states “COMIRNATY® (COVID-19 Vaccine, mRNA) 2024-2025 Formula”
Verify the single dose glass prefilled syringe and label are for the appropriate age group

Please see the Vaccine Presentation Guide for more details.

COMIRNATY 2024-2025 Formula Single Dose Glass Prefilled Syringes

Dose preparation and administration^§

For additional information, please see Full Prescribing Information and Patient Information.

Step 1: Verify Single Dose Glass Prefilled Syringes

Verify that the COMIRNATY single dose glass prefilled syringe label states “2024-2025 Formula.” Verify that the label is for the indicated age group of 12 years and older.¹

Glass prefilled syringes are supplied in a carton containing 10 syringes¹
Each glass prefilled syringe contains a single 0.3 mL dose¹
For individuals previously vaccinated with any COVID-19 vaccine, administer the dose of COMIRNATY at least 2 months after the last dose of COVID-19 vaccine¹

Storage and Expiration

Store COMIRNATY single dose glass prefilled syringes refrigerated at 2°C to 8°C (35°F to 46°F).¹

DO NOT FREEZE. If COMIRNATY single dose glass prefilled syringes have been frozen, discard.¹

Regardless of storage condition, the vaccine should not be used after the expiration date printed on the prefilled syringes and cartons.¹

Verify that product has not expired. Glass prefilled syringes should be used within 8 months from date of manufacture. The vaccine should not be used after the expiration date printed on the prefilled syringes and cartons.^1,2

Received Refrigerated and Stored in Refrigerator

Store single dose glass prefilled syringes in a refrigerator at 2°C to 8°C (35°F to 46°F)¹

The total time out of refrigeration at temperatures between 8°C and 25°C (46°F and 77°F) must not exceed 12 hours.¹

Step 2: Preparation¹

Do not shake
Remove tip cap by slowly turning the cap counterclockwise while holding the Luer lock and attach a sterile needle. Use immediately
If it cannot be used immediately, it must be used within 4 hours

Step 3: Administration¹

Visually inspect for particulate matter and discoloration prior to administration (whenever solution and container permit)
Vaccine will be a white to off-white suspension
DO NOT ADMINISTER if vaccine is discolored or contains particulate matter
For the prefilled syringe, administer the entire volume to deliver a single 0.3 mL dose intramuscularly immediately after preparation

For detailed instructions and information related to product handling, please see Full Prescribing Information.

Ensuring the authenticity of COMIRNATY 2024-2025 Formula

Pfizer is committed to patient safety and ensuring that people have accurate information about COMIRNATY, including how it is accessed and administered. We are actively monitoring for fraudulent offers of illegitimate COMIRNATY to protect patients from products that might be dangerous and lead to serious and life-threatening harm.  

COMIRNATY is only administered intramuscularly by government-authorized healthcare professionals¹
COMIRNATY is not taken orally and is not available in a capsule or tablet form¹
COMIRNATY is not available for private purchase
COMIRNATY is NOT sold online. Any sales of COMIRNATY over the internet, including from online pharmacies, are not legitimate
Authentic COMIRNATY, manufactured by Pfizer or BioNTech, will include the COMIRNATY name on the label and can be visually verified via the Vaccine Presentation Guide¹
The authenticity of products acquired outside of the legitimate supply chain cannot be verified by Pfizer

If you suspect the vaccine you have purchased may be counterfeit, contact us at 1-800-438-1985 or visit https://www.pfizer.com/products/product-contact-information

To learn more, visit https://www.pfizer.com/products/medicine-safety/counterfeiting

Ordering available through Pfizer Prime*

Orders for 2024-2025 formula COVID-19 vaccines by BioNTech and Pfizer can be placed by eligible healthcare professionals directly with Pfizer through Pfizer Prime online or by calling 1-800-533-4535.

Visit Pfizer Prime

Eligible healthcare providers can order COVID-19 vaccines directly from Pfizer. If preferred, orders may be placed with your facility’s wholesaler.

Ordering available through Pfizer Prime*

Orders for 2024-2025 formula COVID-19 vaccines by BioNTech and Pfizer can be placed by eligible healthcare professionals directly with Pfizer through Pfizer Prime online or by calling 1-800-533-4535.

Button

Optional footnote area for disclaimers etc.

Ordering available through Pfizer Prime*

Orders for 2024-2025 formula COVID-19 vaccines by BioNTech and Pfizer can be placed by eligible healthcare professionals directly with Pfizer through Pfizer Prime online or by calling 1-800-533-4535.

Visit Pfizer Prime

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Curabitur neque tellus, elementum sit amet lectus id, congue varius elit. Fusce molestie urna id elit fermentum tincidunt. Proin vel nibh sed elit commodo efficitur nec nec ipsum. Aliquam erat volutpat. Suspendisse eu elit et nisi malesuada luctus. Phasellus nec velit dapibus, condimentum purus non, rutrum mi. In eros sem, pellentesque id congue mollis, vehicula sit amet neque. Quisque condimentum feugiat quam non rhoncus. Cras eget vestibulum urna. Nullam sodales ipsum elit, ac commodo odio fringilla at.

References

Eligible healthcare providers can order COVID-19 vaccines directly from Pfizer. If preferred, orders may be placed with your facility’s wholesaler.

< Back

Real-World Evidence

Up next >

Provider Resources

References:

COMIRNATY® (COVID-19 Vaccine, mRNA). Prescribing Information. BioNTech Manufacturing GmbH and Pfizer Inc.; June 25, 2025.

Pfizer COVID-19 vaccine summary. Centers for Disease Control and Prevention. Updated August 28, 2024. Accessed June 26, 2025. https://www.cdc.gov/vaccines/php/info-by-product/pfizer-covid-19-summary.html

Moderna COVID-19 vaccine summary. Centers for Disease Control and Prevention. Updated August 28, 2024. Accessed June 26, 2025. https://www.cdc.gov/vaccines/php/info-by-product/moderna-covid-19-summary.html

Provider Resources

Find helpful links for ordering, customer service, and information on COVID-19.

Visit Now

Manufactured for
BioNTech Manufacturing GmbH
An der Goldgrube 12
55131 Mainz, Germany
Marketing Authorization Holder

Manufactured by
Pfizer Inc.
New York, NY 10001

COVID-19 vaccines from BioNTech and Pfizer, which are based on BioNTech proprietary mRNA technology, were developed by both BioNTech and Pfizer.

To report an adverse event, please call 1-800-438-1985

Pfizer for Professionals 1-800-505-4426

This site is intended only for U.S. healthcare professionals. The products discussed in this site may have different product labeling in different countries. The information provided is for educational purposes only.

© 2025 Pfizer Inc. All rights reserved.

PP-CVV-USA-5186

You are now leaving PfizerPro

You are now leaving a Pfizer-operated website. Links to all outside sites are provided as a resource to our visitors. Pfizer accepts no responsibility for the content of sites that are not owned and operated by Pfizer.

Important Safety Information

Do not administer COMIRNATY® (COVID-19 Vaccine, mRNA) to individuals with known history of a severe allergic reaction (e.g., anaphylaxis) to any component of COMIRNATY or to individuals who had a severe allergic reaction (e.g., anaphylaxis) following a previous dose of a Pfizer-BioNTech COVID-19 vaccine.

Management of Acute Allergic Reactions

Appropriate medical treatment must be immediately available to manage potential anaphylactic reactions following administration of COMIRNATY.

Myocarditis and Pericarditis

Postmarketing data from use of authorized or approved mRNA COVID-19 vaccines, including COMIRNATY, have demonstrated increased risks of myocarditis and pericarditis, with onset of symptoms typically in the first week following vaccination. The observed risk has been highest in males 12 years through 24 years of age.

Syncope

Syncope (fainting) may occur in association with administration of injectable vaccines, including COMIRNATY. Procedures should be in place to avoid injury from fainting.

Altered Immunocompetence

Immunocompromised persons, including individuals receiving immunosuppressant therapy, may have a diminished immune response to COMIRNATY.

Limitation of Vaccine Effectiveness

COMIRNATY may not protect all vaccine recipients.

Adverse Reactions

The most commonly reported adverse reactions (≥10%) after a dose of COMIRNATY were pain at the injection site (up to 90.5%), fatigue (up to 77.5%), headache (up to 75.5%), chills (up to 49.2%), muscle pain (up to 45.5%), joint pain (up to 27.5%), fever (up to 24.3%), injection site swelling (up to 11.8%), and injection site redness (up to 10.4%).

To report SUSPECTED ADVERSE REACTIONS, contact Pfizer Inc. at 1-800-438-1985
or https:/www.pfizersafetyreporting.com or VAERS at 1-800-822-7967 or https://vaers.hhs.gov

Please click for COMIRNATY Full Prescribing Information and Patient Information.

Indication

COMIRNATY® (COVID-19 Vaccine, mRNA) is a vaccine indicated for active immunization to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in individuals 12 years of age and older.