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HomeCOVID-19 ImpactImpact of
COVID-19Uncovering the Burden of DiseaseCOVID-19 & Flu ImpactSelect UMCs & Risk FactorsAbout COMIRNATYAbout COMIRNATYIntroductionmRNA TechnologyCOMIRNATY Clinical Trial OverviewCOMIRNATY Pivotal TrialSelect Safety DataRWEReal-World EvidenceRCTs and RWE Considerations24-25 Appaneal Study Design24-25 Appaneal VE AnalysisDosingPatient ProfilesPatient
ProfilesHypothetical Patient ProfilesSusan is 68 years oldClaire has chronic kidney diseaseMike has asthmaHypothetical Patient ProfilesSusan is 68 years oldClaire has chronic kidney diseaseMike has asthmaMaria has coronary artery diseaseTom has type 2 diabetesMaria has coronary artery diseaseTom has type 2 diabetesHypothetical Patient ProfilesSusan is 68 years oldMike has asthmaMaria has coronary artery diseaseTom has type 2 diabetesResourcesResourcesLinks & SupportCOMIRNATY Health Plan CoverageMaterialsHypothetical Patient ProfilesSusan is 68 years oldMike has asthmaMaria has coronary artery diseaseTom has type 2 diabetes
IndicationPrescribing InformationPatient InformationPatient SiteOrder on Pfizer PrimePediatric Information (5 years & older)
Help protect eligible individuals against severe outcomes from COVID-19.3
Help protect eligible individuals
against severe outcomes from COVID-19.3
2025-2026 Formula of COMIRNATY, with two age-appropriate dosing presentations3
COMIRNATY is approved for use in individuals who are3: 

• 65 years of age and older, or 

• 5 years through 64 years of age with at least one underlying condition that puts them at high risk for severe outcomes from COVID-19
COMIRNATY is approved for use in individuals who are3: 

• 65 years of age and older, or 

• 5 years through 64 years of age with at least one
underlying condition that puts them at high risk
for severe outcomes from COVID-19
Available in a prefilled syringe for eligible individuals 12 years of age and older3
Available in a prefilled syringe for eligible individuals 12 years of age and older3

View dosing and administration for the 2025-2026 Formula of COMIRNATY

View dosing and administration for the 2025-2026 Formula of COMIRNATY

Dosing & Administration
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Dosing & Administration
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Available as a single-dose vial for eligible pediatric patients 5-11 years of age3
Available as a single-dose vial for eligible pediatric patients 5-11 years of age3

View dosing and administration for the 2025-2026 Formula
of COMIRNATY

View dosing and administration for the 2025-2026 Formula
of COMIRNATY

Dosing & Administration
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Dosing & Administration
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COMIRNATY has been the most administered 

COVID-19 vaccine4-6*

• ~152 million doses in individuals 65 years and older

Inclusive of administered vaccine doses from formulas encoding circulating SARS-CoV-2 spike protein variations for all years from 2020-December 2025 in the US (including District of Columbia and 12 jurisdictions). Data are for individuals aged ≥12 years and are reflective of deductions for returned vaccine doses.4-7Inclusive of administered vaccine doses from formulas encoding circulating SARS-CoV-2 spike protein variations for all years from 2020-December 2025 in the US (including District of Columbia and 12 jurisdictions). Data are for individuals aged ≥12 years and are reflective of deductions for returned vaccine doses.4-7
COMIRNATY has been the most administered COVID-19 vaccine4-6*
  • ~152 million doses in
individuals 65 years and older
Inclusive of administered vaccine doses from formulas encoding circulating SARS-CoV-2 spike protein variations for all years from 2020-December 2025 in the US (including District of Columbia and 12 jurisdictions). Data are for individuals aged ≥12 years and are reflective of deductions for returned vaccine doses.4-7
Your recommendation matters
Discussing COVID-19 vaccination with eligible individuals can be an important first step in helping to prevent COVID-19 with COMIRNATY.2
 Impact of COVID-19

Learn about the disease burden and risk factors for severe outcomes from COVID-19.

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Find out about COMIRNATY dose preparation and administration.


Dosing & Administration
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Learn about the disease burden and risk factors for severe outcomes from COVID-19.

 Button LoadingHypothetical Patient ProfilesExplore examples of hypothetical patients with certain underlying medical conditions or risk factors for severe outcomes from COVID-19.
Go to Patient Profiles
LoadingGo to Patient ProfilesLoadingOrdering available through Pfizer Prime*Orders for 2025-2026 Formula COVID-19 vaccines by BioNTech and Pfizer can be placed by eligible healthcare professionals directly with Pfizer through Pfizer Prime online or by calling 1-800-533-4535.

Visit Pfizer Prime

*If preferred, orders may be placed with your facility’s wholesaler.

COVID-19=coronavirus disease 2019; SARS-CoV-2=severe acute respiratory syndrome coronavirus 2.References:Underlying conditions and the higher risk for severe COVID-19. Centers for Disease Control and Prevention. Updated February 6, 2025. Accessed February 10, 2026. https://www.cdc.gov/covid/hcp/clinical-care/underlying-conditions.html For health care providers. US Department of Health and Human Services. Updated February 20, 2025. Accessed February 10, 2026. https://www.hhs.gov/risk-less-do-more/for-health-care-providers/index.htmlCOMIRNATY® (COVID-19 Vaccine, mRNA). Prescribing Information. BioNTech Manufacturing GmbH and Pfizer Inc.; August 27, 2025.COVID-19 vaccinations in the United States, jurisdiction. Centers for Disease Control and Prevention. Updated May 12, 2023. Accessed February 10, 2026. https://data.cdc.gov/Vaccinations/COVID-19-Vaccinations-in-the-United-States-Jurisdi/unsk-b7fc/about_dataIQVIA National Prescription Audit, retail (September 2023-December 2025).IQVIA National Prescription Audit and Drug Distribution Data (September 2023-December 2025).CDC COVID-19 vaccine administration and distribution data. Jurisdiction abbreviations: COVID-19 vaccinations in the United States, jurisdiction. Centers for Disease Control and Prevention. Updated May 4, 2023. Accessed February 13, 2025. https://data.cdc.gov/api/views/unsk-b7fc/files/cec0661b-25b0-4fd8-9988-c138b4f2ad16

Manufactured for
BioNTech Manufacturing GmbH
An der Goldgrube 12
55131 Mainz, Germany
Marketing Authorization Holder 

Manufactured by
Pfizer Inc.
New York, NY 10001

The formulation of COMIRNATY, which is based on BioNTech proprietary mRNA technology, was developed by BioNTech and Pfizer.  

To report an adverse event, please call 1-800-438-1985

Pfizer for Professionals 1-800-505-4426

This site is intended only for U.S. healthcare professionals. The products discussed in this site may have different product labeling in different countries. The information provided is for educational purposes only.

© 2026 Pfizer Inc. All rights reserved.

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INDICATION
COMIRNATY® (COVID-19 Vaccine, mRNA) is a vaccine indicated for active immunization to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

COMIRNATY is approved for use in individuals who are:
• 65 years of age and older, or
• 5 years through 64 years of age with at least one underlying condition that puts them at high risk for severe outcomes from COVID-19.
Important Safety InformationDo not administer COMIRNATY® (COVID-19 Vaccine, mRNA) to individuals with known history of a severe allergic reaction (e.g., anaphylaxis) to any component of COMIRNATY or to individuals who had a severe allergic reaction (e.g., anaphylaxis) following a previous dose of a Pfizer-BioNTech COVID-19 vaccine.Management of Acute Allergic ReactionsAppropriate medical treatment must be immediately available to manage potential anaphylactic reactions following administration of COMIRNATY.

Myocarditis and Pericarditis

Postmarketing data from use of authorized or approved mRNA COVID-19 vaccines, including COMIRNATY, have demonstrated increased risks of myocarditis and pericarditis, with onset of symptoms typically in the first week following vaccination. The observed risk has been highest in males 12 years through 24 years of age.

SyncopeSyncope (fainting) may occur in association with administration of injectable vaccines, including COMIRNATY. Procedures should be in place to avoid injury from fainting.Altered ImmunocompetenceImmunocompromised persons, including individuals receiving immunosuppressant therapy, may have a diminished immune response to COMIRNATY.Limitation of Vaccine EffectivenessCOMIRNATY may not protect all vaccine recipients.Adverse ReactionsMost commonly reported adverse reactions after a dose:
  • 12 years of age and older (≥10%) were pain at the injection site (up to 90.5%), fatigue (up to 77.5%), headache (up to 75.5%), chills (up to 49.2%), muscle pain (up to 45.5%), joint pain (up to 27.5%), fever (up to 24.3%), injection site swelling (up to 11.8%), and injection site redness (up to 10.4%).
  • 5 years through 11 years of age (≥5%) were pain at the injection site (up to 83.8%), fatigue (up to 51.9%), headache (up to 38.4%), injection site redness (up to 25.9%), injection site swelling (up to 20%), muscle pain (up to 18.1%), chills (up to 13.3%), fever (up to 7.8%), and joint pain (up to 7.6%).
To report SUSPECTED ADVERSE REACTIONS, contact Pfizer Inc. at 1-800-438-1985
or https:/www.pfizersafetyreporting.com or VAERS at 1-800-822-7967 or https://vaers.hhs.govPlease click for COMIRNATY Full Prescribing Information and Patient Information. Indication
COMIRNATY is a vaccine indicated for active immunization to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

COMIRNATY is approved for use in individuals who are:
• 65 years of age and older, or
• 5 years through 64 years of age with at least one underlying condition that puts them at high risk for severe outcomes from COVID-19.